Didn't work as expected after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) in dogs

123 reports to the FDA describe didn't work as expected in dogs given Moxidectin + Pyrantel + Sarolaner. That is 11% of all reports for this medicine, compared with 13% across reports for all dog medicines.

123Reports

23%Marked serious

5.7%Recovered

3.3%Died or euthanised

105 daysTypical onset

How soon it started

Same day

5 7.6%

1–2 days

2 3.0%

3–7 days

3 4.5%

1–4 weeks

12 18%

Over a month

44 67%

How the animals did

Recovered

7 5.7%

Still unwell when reported

19 15%

Died

2 1.6%

Euthanised

2 1.6%

Not known

93 76%

Problems reported at the same time

Loss of appetite

13 11%

Lethargy

12 9.8%

Didn't stop ticks

10 8.1%

10 8.1%

9 7.3%

8 6.5%

6 4.9%

6 4.9%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin + Pyrantel + Sarolaner cause didn't work as expected in dogs?: 123 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 105 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

Didn't work as expected after Ivermectin + Pyrantel (Heartgard Plus) 27,781 reports · 19% of its reports
Didn't work as expected after Milbemycin Oxime + Spinosad (Trifexis) 13,050 reports · 10% of its reports
Didn't work as expected after Moxidectin (ProHeart 6) 2,005 reports · 4.0% of its reports
Didn't work as expected after Milbemycin Oxime + Praziquantel (Interceptor Plus) 3,979 reports · 13% of its reports
Didn't work as expected after Milbemycin Oxime (Interceptor) 3,131 reports · 11% of its reports
Didn't work as expected after Selamectin (Revolution) 2,253 reports · 7.7% of its reports
Didn't work as expected after Ivermectin (Heartgard) 741 reports · 6.2% of its reports
Didn't work as expected after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 1,337 reports · 16% of its reports

All reported side effects of Moxidectin + Pyrantel + Sarolaner in dogs · Medicines most reported with didn't work as expected