Overdose after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) in dogs

31 reports to the FDA describe overdose in dogs given Moxidectin + Pyrantel + Sarolaner. That is 2.7% of all reports for this medicine, compared with 1.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

31Reports

13%Marked serious

26%Recovered

3.2%Died or euthanised

27 daysTypical onset

How soon it started

Same day

7 32%

1–2 days

2 9.1%

3–7 days

0 0.0%

1–4 weeks

3 14%

Over a month

10 45%

How the animals did

Recovered

8 26%

Still unwell when reported

5 16%

Euthanised

1 3.2%

Not known

17 55%

Problems reported at the same time

Vomiting

11 35%

Accidental exposure

8 26%

Didn't prevent heartworm

7 23%

4 13%

4 13%

3 9.7%

2 6.5%

2 6.5%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin + Pyrantel + Sarolaner cause overdose in dogs?: 31 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 27 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Overdose with similar medicines

Overdose after Ivermectin + Pyrantel (Heartgard Plus) 1,647 reports · 1.1% of its reports
Overdose after Milbemycin Oxime + Spinosad (Trifexis) 2,052 reports · 1.6% of its reports
Overdose after Moxidectin (ProHeart 6) 366 reports · 0.7% of its reports
Overdose after Milbemycin Oxime + Praziquantel (Interceptor Plus) 266 reports · 0.8% of its reports
Overdose after Milbemycin Oxime (Interceptor) 131 reports · 0.4% of its reports
Overdose after Selamectin (Revolution) 160 reports · 0.5% of its reports
Overdose after Ivermectin (Heartgard) 134 reports · 1.1% of its reports
Overdose after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 185 reports · 2.2% of its reports

All reported side effects of Moxidectin + Pyrantel + Sarolaner in dogs · Medicines most reported with overdose