Overdose after Selamectin (Revolution) in dogs

The FDA has received 160 reports of overdose in dogs after Selamectin. That is 0.5% of all reports for this medicine, compared with 1.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

160Reports

24%Marked serious

15%Recovered

1.3%Died or euthanised

30 daysTypical onset

How soon it started

Same day

17 25%

1–2 days

6 9.0%

3–7 days

3 4.5%

1–4 weeks

8 12%

Over a month

33 49%

How the animals did

Recovered

24 15%

Still unwell when reported

73 46%

Died

1 0.6%

Euthanised

1 0.6%

Not known

61 38%

Problems reported at the same time

Didn't stop fleas

38 24%

Didn't prevent heartworm

27 17%

Didn't work as expected

25 16%

Didn't stop worms

24 15%

Drug dose administration interval too short

19 12%

Vomiting

14 8.8%

Lethargy

13 8.1%

Diarrhea

11 6.9%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause overdose in dogs?: 160 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 30 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Overdose with similar medicines

Overdose after Ivermectin + Pyrantel (Heartgard Plus) 1,647 reports · 1.1% of its reports
Overdose after Milbemycin Oxime + Spinosad (Trifexis) 2,052 reports · 1.6% of its reports
Overdose after Moxidectin (ProHeart 6) 366 reports · 0.7% of its reports
Overdose after Milbemycin Oxime + Praziquantel (Interceptor Plus) 266 reports · 0.8% of its reports
Overdose after Milbemycin Oxime (Interceptor) 131 reports · 0.4% of its reports
Overdose after Ivermectin (Heartgard) 134 reports · 1.1% of its reports
Overdose after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 185 reports · 2.2% of its reports
Overdose after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 31 reports · 2.7% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with overdose