Overdose after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs

266 reports to the FDA describe overdose in dogs given Milbemycin Oxime + Praziquantel. That is 0.8% of all reports for this medicine, compared with 1.3% across reports for all dog medicines.

266Reports

13%Marked serious

17%Recovered

0.8%Died or euthanised

1 daysTypical onset

How soon it started

Same day

90 45%

1–2 days

16 8.0%

3–7 days

11 5.5%

1–4 weeks

15 7.5%

Over a month

68 34%

How the animals did

Recovered

45 17%

Still unwell when reported

61 23%

Died

2 0.8%

Not known

158 59%

Problems reported at the same time

Didn't prevent heartworm

74 28%

66 25%

55 21%

49 18%

37 14%

26 9.8%

20 7.5%

18 6.8%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Praziquantel cause overdose in dogs?: 266 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Overdose with similar medicines

Overdose after Ivermectin + Pyrantel (Heartgard Plus) 1,647 reports · 1.1% of its reports
Overdose after Milbemycin Oxime + Spinosad (Trifexis) 2,052 reports · 1.6% of its reports
Overdose after Moxidectin (ProHeart 6) 366 reports · 0.7% of its reports
Overdose after Milbemycin Oxime (Interceptor) 131 reports · 0.4% of its reports
Overdose after Selamectin (Revolution) 160 reports · 0.5% of its reports
Overdose after Ivermectin (Heartgard) 134 reports · 1.1% of its reports
Overdose after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 185 reports · 2.2% of its reports
Overdose after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 31 reports · 2.7% of its reports

All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with overdose