Drug dose administration interval too short after Selamectin (Revolution) in dogs

The FDA has received 192 reports of drug dose administration interval too short in dogs after Selamectin. That is 0.7% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

192Reports

4.7%Marked serious

1.6%Recovered

0.5%Died or euthanised

43 daysTypical onset

How soon it started

Same day

8 7.4%

1–2 days

4 3.7%

3–7 days

6 5.6%

1–4 weeks

25 23%

Over a month

65 60%

How the animals did

Recovered

3 1.6%

Still unwell when reported

70 36%

Euthanised

1 0.5%

Not known

118 61%

Problems reported at the same time

Didn't stop fleas

82 43%

Didn't work as expected

59 31%

33 17%

19 9.9%

8 4.2%

6 3.1%

6 3.1%

5 2.6%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause drug dose administration interval too short in dogs?: 192 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 43 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drug dose administration interval too short with similar medicines

Drug dose administration interval too short after Ivermectin + Pyrantel (Heartgard Plus) 132 reports · 0.1% of its reports
Drug dose administration interval too short after Milbemycin Oxime + Spinosad (Trifexis) 157 reports · 0.1% of its reports
Drug dose administration interval too short after Moxidectin (ProHeart 6) 368 reports · 0.7% of its reports
Drug dose administration interval too short after Milbemycin Oxime + Praziquantel (Interceptor Plus) 54 reports · 0.2% of its reports
Drug dose administration interval too short after Milbemycin Oxime (Interceptor) 24 reports · 0.1% of its reports
Drug dose administration interval too short after Ivermectin (Heartgard) 34 reports · 0.3% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with drug dose administration interval too short