Drooling after Milbemycin Oxime (Interceptor) in dogs

The FDA has received 354 reports of drooling in dogs after Milbemycin Oxime. That is 1.2% of all reports for this medicine, compared with 1.4% across reports for all dog medicines.

354Reports

15%Marked serious

14%Recovered

12%Died or euthanised

1 daysTypical onset

How soon it started

Same day

32 40%

1–2 days

11 14%

3–7 days

4 4.9%

1–4 weeks

7 8.6%

Over a month

27 33%

How the animals did

Recovered

50 14%

Still unwell when reported

31 8.8%

Died

41 12%

Euthanised

3 0.8%

Not known

229 65%

Problems reported at the same time

143 40%

124 35%

86 24%

71 20%

64 18%

57 16%

55 16%

52 15%

Age of the animals

Under 1 year

1–3 years

106

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause drooling in dogs?: 354 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drooling with similar medicines

Drooling after Ivermectin + Pyrantel (Heartgard Plus) 1,096 reports · 0.7% of its reports
Drooling after Milbemycin Oxime + Spinosad (Trifexis) 1,577 reports · 1.2% of its reports
Drooling after Moxidectin (ProHeart 6) 730 reports · 1.4% of its reports
Drooling after Milbemycin Oxime + Praziquantel (Interceptor Plus) 420 reports · 1.3% of its reports
Drooling after Selamectin (Revolution) 469 reports · 1.6% of its reports
Drooling after Ivermectin (Heartgard) 494 reports · 4.1% of its reports
Drooling after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 166 reports · 1.9% of its reports
Drooling after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 21 reports · 1.8% of its reports

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with drooling