Tremors after Moxidectin + Praziquantel in dogs
27 reports to the FDA describe tremors in dogs given Moxidectin + Praziquantel. That is 36% of all reports for this medicine, compared with 3.4% across reports for all dog medicines, so it is reported unusually often with this medicine.
27Reports
22%Marked serious
7.4%Recovered
11%Died or euthanised
–Typical onset
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How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Praziquantel treats tapeworms.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Moxidectin + Praziquantel cause tremors in dogs?
- 27 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Tremors with similar medicines
- Tremors after Ivermectin + Pyrantel (Heartgard Plus) 2,169 reports · 1.5% of its reports
- Tremors after Milbemycin Oxime + Spinosad (Trifexis) 5,684 reports · 4.4% of its reports
- Tremors after Moxidectin (ProHeart 6) 1,208 reports · 2.4% of its reports
- Tremors after Milbemycin Oxime + Praziquantel (Interceptor Plus) 766 reports · 2.4% of its reports
- Tremors after Milbemycin Oxime (Interceptor) 729 reports · 2.4% of its reports
- Tremors after Selamectin (Revolution) 984 reports · 3.3% of its reports
- Tremors after Ivermectin (Heartgard) 959 reports · 8.0% of its reports
- Tremors after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 245 reports · 2.9% of its reports
- Tremors after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 56 reports · 4.8% of its reports
- Tremors after Ivermectin + Praziquantel 61 reports · 30% of its reports
All reported side effects of Moxidectin + Praziquantel in dogs · Medicines most reported with tremors