Moxidectin + Praziquantel side effects in dogs
75 reports sent to the FDA between 2004 and 2025 involve Moxidectin + Praziquantel in dogs. The most reported problems were wobbliness (ataxia), tremors, accidental exposure. 21% were marked serious.
About this medicine
Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Praziquantel treats tapeworms.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (23 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Border Collie 10 reports
- Australian Shepherd Dog 4 reports
- Chihuahua 4 reports
- Labrador Retriever 4 reports
- Rat Terrier 3 reports
- Jack Russell Terrier 3 reports
- Australian (blue Heeler, Red Heeler, Queensland Cattledog) Cattle Dog 3 reports
- German Shepherd Dog 3 reports
- Boston Terrier 2 reports
- Dachshund 2 reports