Allergic reaction after Selamectin (Revolution) in dogs

473 reports to the FDA describe allergic reaction in dogs given Selamectin. That is 1.6% of all reports for this medicine, compared with 2.3% across reports for all dog medicines.

473Reports

8.0%Marked serious

9.7%Recovered

3.8%Died or euthanised

Same dayTypical onset

How soon it started

Same day

79 57%

1–2 days

36 26%

3–7 days

8 5.8%

1–4 weeks

7 5.0%

Over a month

9 6.5%

How the animals did

Recovered

46 9.7%

Still unwell when reported

54 11%

Died

17 3.6%

Euthanised

1 0.2%

Not known

355 75%

Problems reported at the same time

140 30%

105 22%

96 20%

61 13%

48 10%

Skin rash or irritation

47 9.9%

Loss of appetite

36 7.6%

Skin hyperaemia

35 7.4%

Age of the animals

Under 1 year

121

1–3 years

181

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause allergic reaction in dogs?: 473 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Allergic reaction with similar medicines

Allergic reaction after Ivermectin + Pyrantel (Heartgard Plus) 788 reports · 0.5% of its reports
Allergic reaction after Milbemycin Oxime + Spinosad (Trifexis) 1,103 reports · 0.9% of its reports
Allergic reaction after Moxidectin (ProHeart 6) 9,936 reports · 20% of its reports
Allergic reaction after Milbemycin Oxime + Praziquantel (Interceptor Plus) 402 reports · 1.3% of its reports
Allergic reaction after Milbemycin Oxime (Interceptor) 274 reports · 0.9% of its reports
Allergic reaction after Ivermectin (Heartgard) 160 reports · 1.3% of its reports
Allergic reaction after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 70 reports · 0.8% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with allergic reaction