Skin hyperaemia after Selamectin (Revolution) in dogs

216 reports to the FDA describe skin hyperaemia in dogs given Selamectin. That is 0.7% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

216Reports

0.0%Marked serious

0.0%Recovered

1.4%Died or euthanised

–Typical onset

How the animals did

Died

3 1.4%

Not known

213 99%

Problems reported at the same time

Itching

116 54%

Skin rash or irritation

65 30%

40 19%

35 16%

27 13%

24 11%

18 8.3%

16 7.4%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause skin hyperaemia in dogs?: 216 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin hyperaemia with similar medicines

Skin hyperaemia after Ivermectin + Pyrantel (Heartgard Plus) 62 reports · 0.0% of its reports
Skin hyperaemia after Milbemycin Oxime + Spinosad (Trifexis) 59 reports · 0.0% of its reports
Skin hyperaemia after Moxidectin (ProHeart 6) 213 reports · 0.4% of its reports
Skin hyperaemia after Milbemycin Oxime (Interceptor) 75 reports · 0.3% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with skin hyperaemia