Skin rash or irritation after Selamectin (Revolution) in dogs

728 reports to the FDA describe skin rash or irritation in dogs given Selamectin. That is 2.5% of all reports for this medicine, compared with 1.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

728Reports

6.0%Marked serious

3.4%Recovered

1.1%Died or euthanised

2 daysTypical onset

How soon it started

Same day

62 35%

1–2 days

37 21%

3–7 days

18 10%

1–4 weeks

27 15%

Over a month

33 19%

How the animals did

Recovered

25 3.4%

Still unwell when reported

107 15%

Died

5 0.7%

Euthanised

3 0.4%

Not known

588 81%

Problems reported at the same time

Itching

291 40%

Hair loss

113 16%

Application site reaction

89 12%

65 8.9%

64 8.8%

58 8.0%

47 6.5%

47 6.5%

Age of the animals

Under 1 year

108

1–3 years

246

4–7 years

197

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause skin rash or irritation in dogs?: 728 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin rash or irritation with similar medicines

Skin rash or irritation after Ivermectin + Pyrantel (Heartgard Plus) 664 reports · 0.4% of its reports
Skin rash or irritation after Milbemycin Oxime + Spinosad (Trifexis) 1,342 reports · 1.0% of its reports
Skin rash or irritation after Moxidectin (ProHeart 6) 446 reports · 0.9% of its reports
Skin rash or irritation after Milbemycin Oxime + Praziquantel (Interceptor Plus) 234 reports · 0.7% of its reports
Skin rash or irritation after Milbemycin Oxime (Interceptor) 234 reports · 0.8% of its reports
Skin rash or irritation after Ivermectin (Heartgard) 138 reports · 1.1% of its reports
Skin rash or irritation after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 20 reports · 0.2% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with skin rash or irritation