Skin rash or irritation after Moxidectin (ProHeart 6) in dogs

The FDA has received 446 reports of skin rash or irritation in dogs after Moxidectin. That is 0.9% of all reports for this medicine, compared with 1.3% across reports for all dog medicines.

446Reports

29%Marked serious

9.6%Recovered

8.3%Died or euthanised

2 daysTypical onset

How soon it started

Same day

84 36%

1–2 days

37 16%

3–7 days

24 10%

1–4 weeks

38 16%

Over a month

48 21%

How the animals did

Recovered

42 9.4%

Recovered with lasting effects

1 0.2%

Still unwell when reported

170 38%

Died

26 5.8%

Euthanised

11 2.5%

Not known

196 44%

Problems reported at the same time

132 30%

91 20%

90 20%

88 20%

80 18%

69 15%

59 13%

43 9.6%

Age of the animals

Under 1 year

1–3 years

154

4–7 years

155

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause skin rash or irritation in dogs?: 446 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin rash or irritation with similar medicines

Skin rash or irritation after Ivermectin + Pyrantel (Heartgard Plus) 664 reports · 0.4% of its reports
Skin rash or irritation after Milbemycin Oxime + Spinosad (Trifexis) 1,342 reports · 1.0% of its reports
Skin rash or irritation after Milbemycin Oxime + Praziquantel (Interceptor Plus) 234 reports · 0.7% of its reports
Skin rash or irritation after Milbemycin Oxime (Interceptor) 234 reports · 0.8% of its reports
Skin rash or irritation after Selamectin (Revolution) 728 reports · 2.5% of its reports
Skin rash or irritation after Ivermectin (Heartgard) 138 reports · 1.1% of its reports
Skin rash or irritation after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 20 reports · 0.2% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with skin rash or irritation