Hair loss after Moxidectin (ProHeart 6) in dogs

325 reports to the FDA describe hair loss in dogs given Moxidectin. That is 0.6% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported less often than average with this medicine.

325Reports

21%Marked serious

6.5%Recovered

4.0%Died or euthanised

11 daysTypical onset

How soon it started

Same day

26 17%

1–2 days

22 14%

3–7 days

25 16%

1–4 weeks

32 21%

Over a month

50 32%

How the animals did

Recovered

20 6.2%

Recovered with lasting effects

1 0.3%

Still unwell when reported

120 37%

Died

10 3.1%

Euthanised

3 0.9%

Not known

171 53%

Problems reported at the same time

Itching

97 30%

Injection site reaction

82 25%

Skin rash or irritation

59 18%

41 13%

37 11%

26 8.0%

25 7.7%

23 7.1%

Age of the animals

Under 1 year

1–3 years

128

4–7 years

100

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause hair loss in dogs?: 325 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 11 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hair loss with similar medicines

Hair loss after Ivermectin + Pyrantel (Heartgard Plus) 539 reports · 0.4% of its reports
Hair loss after Milbemycin Oxime + Spinosad (Trifexis) 1,029 reports · 0.8% of its reports
Hair loss after Milbemycin Oxime + Praziquantel (Interceptor Plus) 158 reports · 0.5% of its reports
Hair loss after Milbemycin Oxime (Interceptor) 132 reports · 0.4% of its reports
Hair loss after Selamectin (Revolution) 1,036 reports · 3.5% of its reports
Hair loss after Ivermectin (Heartgard) 104 reports · 0.9% of its reports
Hair loss after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 20 reports · 0.2% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with hair loss