Hyperphosphataemia after Milbemycin Oxime (Interceptor) in dogs

59 reports to the FDA describe hyperphosphataemia in dogs given Milbemycin Oxime. That is 0.2% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

59Reports
24%Marked serious
6.8%Recovered
32%Died or euthanised
–Typical onset
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How the animals did

Recovered
2 3.4%
Recovered with lasting effects
2 3.4%
Still unwell when reported
12 20%
Died
19 32%
Not known
24 41%

Problems reported at the same time

Kidney problems
38 64%
Liver problems
31 53%
Vomiting
28 47%
Lethargy
26 44%
Loss of appetite
20 34%
Death
19 32%
Diarrhea
14 24%
Blood problems
13 22%

Age of the animals

Under 1 year
18
1–3 years
6
4–7 years
9
8–11 years
17
12+ years
8

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause hyperphosphataemia in dogs?
59 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperphosphataemia with similar medicines

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with hyperphosphataemia