Hyperphosphataemia after Selamectin (Revolution) in dogs

57 reports to the FDA describe hyperphosphataemia in dogs given Selamectin. That is 0.2% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

57Reports

28%Marked serious

3.5%Recovered

46%Died or euthanised

4 daysTypical onset

How soon it started

Same day

4 25%

1–2 days

2 13%

3–7 days

3 19%

1–4 weeks

3 19%

Over a month

4 25%

How the animals did

Recovered

2 3.5%

Still unwell when reported

7 12%

Died

23 40%

Euthanised

3 5.3%

Not known

22 39%

Problems reported at the same time

45 79%

28 49%

27 47%

26 46%

25 44%

25 44%

23 40%

18 32%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause hyperphosphataemia in dogs?: 57 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperphosphataemia with similar medicines

Hyperphosphataemia after Ivermectin + Pyrantel (Heartgard Plus) 164 reports · 0.1% of its reports
Hyperphosphataemia after Milbemycin Oxime + Spinosad (Trifexis) 236 reports · 0.2% of its reports
Hyperphosphataemia after Moxidectin (ProHeart 6) 219 reports · 0.4% of its reports
Hyperphosphataemia after Milbemycin Oxime + Praziquantel (Interceptor Plus) 56 reports · 0.2% of its reports
Hyperphosphataemia after Milbemycin Oxime (Interceptor) 59 reports · 0.2% of its reports
Hyperphosphataemia after Ivermectin (Heartgard) 44 reports · 0.4% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with hyperphosphataemia