Pale mucous membrane after Milbemycin Oxime (Interceptor) in dogs

The FDA has received 137 reports of pale mucous membrane in dogs after Milbemycin Oxime. That is 0.5% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported less often than average with this medicine.

137Reports

26%Marked serious

9.5%Recovered

26%Died or euthanised

23 daysTypical onset

How soon it started

Same day

5 17%

1–2 days

3 10%

3–7 days

1 3.4%

1–4 weeks

8 28%

Over a month

12 41%

How the animals did

Recovered

13 9.5%

Still unwell when reported

11 8.0%

Died

26 19%

Euthanised

10 7.3%

Not known

77 56%

Problems reported at the same time

83 61%

55 40%

38 28%

37 27%

37 27%

30 22%

28 20%

26 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause pale mucous membrane in dogs?: 137 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 23 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pale mucous membrane with similar medicines

Pale mucous membrane after Ivermectin + Pyrantel (Heartgard Plus) 282 reports · 0.2% of its reports
Pale mucous membrane after Milbemycin Oxime + Spinosad (Trifexis) 352 reports · 0.3% of its reports
Pale mucous membrane after Moxidectin (ProHeart 6) 1,957 reports · 3.9% of its reports
Pale mucous membrane after Milbemycin Oxime + Praziquantel (Interceptor Plus) 140 reports · 0.4% of its reports
Pale mucous membrane after Selamectin (Revolution) 97 reports · 0.3% of its reports
Pale mucous membrane after Ivermectin (Heartgard) 66 reports · 0.5% of its reports
Pale mucous membrane after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 84 reports · 1.0% of its reports

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with pale mucous membrane