Pale mucous membrane after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) in dogs

84 reports to the FDA describe pale mucous membrane in dogs given Ivermectin + Praziquantel + Pyrantel. That is 1.0% of all reports for this medicine, compared with 0.7% across reports for all dog medicines.

84Reports

62%Marked serious

39%Recovered

12%Died or euthanised

Same dayTypical onset

How soon it started

Same day

48 87%

1–2 days

3 5.5%

3–7 days

0 0.0%

1–4 weeks

0 0.0%

Over a month

4 7.3%

How the animals did

Recovered

33 39%

Still unwell when reported

3 3.6%

Died

6 7.1%

Euthanised

4 4.8%

Not known

38 45%

Problems reported at the same time

53 63%

45 54%

20 24%

19 23%

18 21%

10 12%

9 11%

9 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Iverhart Max. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Praziquantel + Pyrantel cause pale mucous membrane in dogs?: 84 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pale mucous membrane with similar medicines

Pale mucous membrane after Ivermectin + Pyrantel (Heartgard Plus) 282 reports · 0.2% of its reports
Pale mucous membrane after Milbemycin Oxime + Spinosad (Trifexis) 352 reports · 0.3% of its reports
Pale mucous membrane after Moxidectin (ProHeart 6) 1,957 reports · 3.9% of its reports
Pale mucous membrane after Milbemycin Oxime + Praziquantel (Interceptor Plus) 140 reports · 0.4% of its reports
Pale mucous membrane after Milbemycin Oxime (Interceptor) 137 reports · 0.5% of its reports
Pale mucous membrane after Selamectin (Revolution) 97 reports · 0.3% of its reports
Pale mucous membrane after Ivermectin (Heartgard) 66 reports · 0.5% of its reports

All reported side effects of Ivermectin + Praziquantel + Pyrantel in dogs · Medicines most reported with pale mucous membrane