Collapse after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) in dogs

60 reports to the FDA describe collapse in dogs given Ivermectin + Praziquantel + Pyrantel. That is 0.7% of all reports for this medicine, compared with 0.9% across reports for all dog medicines.

60Reports

53%Marked serious

48%Recovered

6.7%Died or euthanised

Same dayTypical onset

How soon it started

Same day

27 71%

1–2 days

2 5.3%

3–7 days

1 2.6%

1–4 weeks

0 0.0%

Over a month

8 21%

How the animals did

Recovered

29 48%

Still unwell when reported

1 1.7%

Died

4 6.7%

Not known

26 43%

Problems reported at the same time

36 60%

17 28%

16 27%

12 20%

11 18%

9 15%

8 13%

Shock

5 8.3%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Iverhart Max. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Praziquantel + Pyrantel cause collapse in dogs?: 60 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Collapse with similar medicines

Collapse after Ivermectin + Pyrantel (Heartgard Plus) 432 reports · 0.3% of its reports
Collapse after Milbemycin Oxime + Spinosad (Trifexis) 471 reports · 0.4% of its reports
Collapse after Moxidectin (ProHeart 6) 1,511 reports · 3.0% of its reports
Collapse after Milbemycin Oxime + Praziquantel (Interceptor Plus) 153 reports · 0.5% of its reports
Collapse after Milbemycin Oxime (Interceptor) 163 reports · 0.5% of its reports
Collapse after Selamectin (Revolution) 115 reports · 0.4% of its reports
Collapse after Ivermectin (Heartgard) 109 reports · 0.9% of its reports

All reported side effects of Ivermectin + Praziquantel + Pyrantel in dogs · Medicines most reported with collapse