Collapse after Selamectin (Revolution) in dogs

115 reports to the FDA describe collapse in dogs given Selamectin. That is 0.4% of all reports for this medicine, compared with 0.9% across reports for all dog medicines, so it is reported less often than average with this medicine.

115Reports

30%Marked serious

17%Recovered

30%Died or euthanised

1 daysTypical onset

How soon it started

Same day

21 49%

1–2 days

7 16%

3–7 days

7 16%

1–4 weeks

5 12%

Over a month

3 7.0%

How the animals did

Recovered

19 17%

Still unwell when reported

13 11%

Died

32 28%

Euthanised

2 1.7%

Not known

49 43%

Problems reported at the same time

34 30%

32 28%

28 24%

21 18%

20 17%

15 13%

15 13%

15 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause collapse in dogs?: 115 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Collapse with similar medicines

Collapse after Ivermectin + Pyrantel (Heartgard Plus) 432 reports · 0.3% of its reports
Collapse after Milbemycin Oxime + Spinosad (Trifexis) 471 reports · 0.4% of its reports
Collapse after Moxidectin (ProHeart 6) 1,511 reports · 3.0% of its reports
Collapse after Milbemycin Oxime + Praziquantel (Interceptor Plus) 153 reports · 0.5% of its reports
Collapse after Milbemycin Oxime (Interceptor) 163 reports · 0.5% of its reports
Collapse after Ivermectin (Heartgard) 109 reports · 0.9% of its reports
Collapse after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 60 reports · 0.7% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with collapse