Disorientation after Selamectin (Revolution) in dogs

202 reports to the FDA describe disorientation in dogs given Selamectin. That is 0.7% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.

202Reports

17%Marked serious

17%Recovered

8.9%Died or euthanised

Same dayTypical onset

How soon it started

Same day

50 52%

1–2 days

22 23%

3–7 days

9 9.4%

1–4 weeks

7 7.3%

Over a month

8 8.3%

How the animals did

Recovered

34 17%

Still unwell when reported

28 14%

Died

13 6.4%

Euthanised

5 2.5%

Not known

122 60%

Problems reported at the same time

69 34%

55 27%

45 22%

43 21%

38 19%

32 16%

32 16%

19 9.4%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause disorientation in dogs?: 202 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Disorientation with similar medicines

Disorientation after Ivermectin + Pyrantel (Heartgard Plus) 588 reports · 0.4% of its reports
Disorientation after Milbemycin Oxime + Spinosad (Trifexis) 1,317 reports · 1.0% of its reports
Disorientation after Moxidectin (ProHeart 6) 293 reports · 0.6% of its reports
Disorientation after Milbemycin Oxime + Praziquantel (Interceptor Plus) 183 reports · 0.6% of its reports
Disorientation after Milbemycin Oxime (Interceptor) 154 reports · 0.5% of its reports
Disorientation after Ivermectin (Heartgard) 246 reports · 2.0% of its reports
Disorientation after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 45 reports · 0.5% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with disorientation