Imidacloprid + Moxidectin (Advantage Multi) side effects in dogs
13,117 reports sent to the FDA between 2006 and 2026 involve Imidacloprid + Moxidectin in dogs. The most reported problems were itching, lethargy, vomiting. 57% were marked serious, and where it was recorded, signs eased after stopping the medicine in 98% of cases.
About this medicine
Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).
Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (8,230 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Labrador Retriever 862 reports
- Chihuahua 615 reports
- Yorkshire Terrier 604 reports
- Shih Tzu 481 reports
- German Shepherd Dog 369 reports
- Pit Bull 323 reports
- Greyhound 286 reports
- Golden Retriever 275 reports
- Dachshund 252 reports
- Maltese 236 reports