Lufenuron + Milbemycin Oxime (Sentinel) side effects in dogs
26,051 reports sent to the FDA between 1997 and 2026 involve Lufenuron + Milbemycin Oxime in dogs. The most reported problems were vomiting, diarrhea, lethargy. 24% were marked serious, and where it was recorded, signs eased after stopping the medicine in 11% of cases.
About this medicine
Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).
Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (7,918 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Labrador Retriever 2,912 reports
- Golden Retriever 1,043 reports
- German Shepherd Dog 995 reports
- Beagle 625 reports
- Yorkshire Terrier 610 reports
- Chihuahua 553 reports
- Shih Tzu 530 reports
- Boxer (german Boxer) 511 reports
- Dachshund 466 reports
- Australian Shepherd Dog 417 reports