Overdose after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

355 reports to the FDA describe overdose in dogs given Lufenuron + Milbemycin Oxime. That is 1.4% of all reports for this medicine, compared with 1.3% across reports for all dog medicines.

355Reports

26%Marked serious

37%Recovered

0.6%Died or euthanised

1 daysTypical onset

How soon it started

Same day

53 43%

1–2 days

14 11%

3–7 days

7 5.6%

1–4 weeks

28 23%

Over a month

22 18%

How the animals did

Recovered

131 37%

Recovered with lasting effects

1 0.3%

Still unwell when reported

62 17%

Died

2 0.6%

Not known

159 45%

Problems reported at the same time

95 27%

68 19%

62 17%

56 16%

Didn't prevent heartworm

55 15%

Didn't work as expected

48 14%

Diarrhea

41 12%

Loss of appetite

29 8.2%

Age of the animals

Under 1 year

1–3 years

113

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause overdose in dogs?: 355 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Overdose with similar medicines

Overdose after Spinosad (Comfortis) 706 reports · 1.2% of its reports
Overdose after Imidacloprid + Moxidectin (Advantage Multi) 201 reports · 1.5% of its reports
Overdose after Nitenpyram (Capstar) 343 reports · 3.2% of its reports
Overdose after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 148 reports · 1.5% of its reports
Overdose after Imidacloprid 103 reports · 5.4% of its reports
Overdose after Fipronil 29 reports · 2.1% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with overdose