Overdose after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

148 reports to the FDA describe overdose in dogs given Lufenuron + Milbemycin Oxime + Praziquantel. That is 1.5% of all reports for this medicine, compared with 1.3% across reports for all dog medicines.

148Reports

36%Marked serious

43%Recovered

0.7%Died or euthanised

1 daysTypical onset

How soon it started

Same day

29 43%

1–2 days

14 21%

3–7 days

4 5.9%

1–4 weeks

11 16%

Over a month

10 15%

How the animals did

Recovered

63 43%

Still unwell when reported

31 21%

Euthanised

1 0.7%

Not known

53 36%

Problems reported at the same time

Accidental exposure

47 32%

Didn't stop worms

29 20%

Vomiting

29 20%

Didn't work as expected

19 13%

Lethargy

19 13%

Didn't prevent heartworm

15 10%

Diarrhea

14 9.5%

Wobbliness (ataxia)

12 8.1%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause overdose in dogs?: 148 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Overdose with similar medicines

Overdose after Spinosad (Comfortis) 706 reports · 1.2% of its reports
Overdose after Lufenuron + Milbemycin Oxime (Sentinel) 355 reports · 1.4% of its reports
Overdose after Imidacloprid + Moxidectin (Advantage Multi) 201 reports · 1.5% of its reports
Overdose after Nitenpyram (Capstar) 343 reports · 3.2% of its reports
Overdose after Imidacloprid 103 reports · 5.4% of its reports
Overdose after Fipronil 29 reports · 2.1% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with overdose