Didn't prevent heartworm after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

The FDA has received 2,544 reports of didn't prevent heartworm in dogs after Lufenuron + Milbemycin Oxime + Praziquantel. That is 26% of all reports for this medicine, compared with 13% across reports for all dog medicines, so it is reported unusually often with this medicine.

2,544Reports

56%Marked serious

3.6%Recovered

1.1%Died or euthanised

310 daysTypical onset

How soon it started

Same day

5 0.8%

1–2 days

0 0.0%

3–7 days

2 0.3%

1–4 weeks

9 1.5%

Over a month

604 97%

How the animals did

Recovered

74 2.9%

Recovered with lasting effects

18 0.7%

Still unwell when reported

1,268 50%

Died

13 0.5%

Euthanised

15 0.6%

Not known

1,156 45%

Problems reported at the same time

Drug dose omission

188 7.4%

Underdose

62 2.4%

Didn't work as expected

48 1.9%

Death

22 0.9%

Cough

19 0.7%

Drug dose administration interval too long

19 0.7%

Liver problems

18 0.7%

Didn't stop worms

15 0.6%

Age of the animals

Under 1 year

1–3 years

1,378

4–7 years

713

8–11 years

326

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause didn't prevent heartworm in dogs?: 2,544 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 310 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't prevent heartworm with similar medicines

Didn't prevent heartworm after Spinosad (Comfortis) 99 reports · 0.2% of its reports
Didn't prevent heartworm after Lufenuron + Milbemycin Oxime (Sentinel) 7,458 reports · 29% of its reports
Didn't prevent heartworm after Imidacloprid + Moxidectin (Advantage Multi) 1,665 reports · 13% of its reports
Didn't prevent heartworm after Nitenpyram (Capstar) 30 reports · 0.3% of its reports
Didn't prevent heartworm after Fipronil + S-methoprene (Frontline Plus) 31 reports · 1.0% of its reports
Didn't prevent heartworm after Flumethrin + Imidacloprid (Seresto) 62 reports · 2.7% of its reports
Didn't prevent heartworm after Fipronil 30 reports · 2.1% of its reports
Didn't prevent heartworm after Imidacloprid + Permethrin 20 reports · 4.3% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with didn't prevent heartworm