Didn't prevent heartworm after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

7,458 reports to the FDA describe didn't prevent heartworm in dogs given Lufenuron + Milbemycin Oxime. That is 29% of all reports for this medicine, compared with 13% across reports for all dog medicines, so it is reported unusually often with this medicine.

7,458Reports

30%Marked serious

3.4%Recovered

1.3%Died or euthanised

316 daysTypical onset

How soon it started

Same day

7 0.9%

1–2 days

1 0.1%

3–7 days

3 0.4%

1–4 weeks

10 1.4%

Over a month

718 97%

How the animals did

Recovered

228 3.1%

Recovered with lasting effects

28 0.4%

Still unwell when reported

1,985 27%

Died

72 1.0%

Euthanised

22 0.3%

Not known

5,123 69%

Problems reported at the same time

Didn't work as expected

448 6.0%

247 3.3%

145 1.9%

81 1.1%

59 0.8%

55 0.7%

Drug dose administration interval too long

54 0.7%

Abnormal radiograph finding

49 0.7%

Age of the animals

Under 1 year

1–3 years

3,735

4–7 years

2,263

8–11 years

1,096

12+ years

255

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause didn't prevent heartworm in dogs?: 7,458 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 316 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't prevent heartworm with similar medicines

Didn't prevent heartworm after Spinosad (Comfortis) 99 reports · 0.2% of its reports
Didn't prevent heartworm after Imidacloprid + Moxidectin (Advantage Multi) 1,665 reports · 13% of its reports
Didn't prevent heartworm after Nitenpyram (Capstar) 30 reports · 0.3% of its reports
Didn't prevent heartworm after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 2,544 reports · 26% of its reports
Didn't prevent heartworm after Fipronil + S-methoprene (Frontline Plus) 31 reports · 1.0% of its reports
Didn't prevent heartworm after Flumethrin + Imidacloprid (Seresto) 62 reports · 2.7% of its reports
Didn't prevent heartworm after Fipronil 30 reports · 2.1% of its reports
Didn't prevent heartworm after Imidacloprid + Permethrin 20 reports · 4.3% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with didn't prevent heartworm