Didn't work as expected after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

4,480 reports to the FDA describe didn't work as expected in dogs given Lufenuron + Milbemycin Oxime. That is 17% of all reports for this medicine, compared with 13% across reports for all dog medicines.

4,480Reports

15%Marked serious

17%Recovered

0.7%Died or euthanised

19 daysTypical onset

How soon it started

Same day

57 3.5%

1–2 days

91 5.6%

3–7 days

225 14%

1–4 weeks

887 55%

Over a month

355 22%

How the animals did

Recovered

762 17%

Recovered with lasting effects

4 0.1%

Still unwell when reported

509 11%

Died

20 0.4%

Euthanised

12 0.3%

Not known

3,173 71%

Problems reported at the same time

Didn't stop worms

1,109 25%

Didn't prevent heartworm

448 10%

432 9.6%

222 5.0%

104 2.3%

84 1.9%

84 1.9%

Drug dose administration interval too long

69 1.5%

Age of the animals

Under 1 year

474

1–3 years

1,600

4–7 years

1,227

8–11 years

839

12+ years

258

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause didn't work as expected in dogs?: 4,480 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 19 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

Didn't work as expected after Spinosad (Comfortis) 1,731 reports · 3.0% of its reports
Didn't work as expected after Imidacloprid + Moxidectin (Advantage Multi) 631 reports · 4.8% of its reports
Didn't work as expected after Nitenpyram (Capstar) 803 reports · 7.4% of its reports
Didn't work as expected after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 1,429 reports · 14% of its reports
Didn't work as expected after Fipronil + S-methoprene (Frontline Plus) 243 reports · 8.2% of its reports
Didn't work as expected after Flumethrin + Imidacloprid (Seresto) 209 reports · 9.2% of its reports
Didn't work as expected after Imidacloprid 105 reports · 5.5% of its reports
Didn't work as expected after Fipronil 152 reports · 11% of its reports
Didn't work as expected after Imidacloprid + Permethrin + Pyriproxyfen 30 reports · 4.1% of its reports
Didn't work as expected after Imidacloprid + Permethrin 70 reports · 15% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with didn't work as expected