Loose stool after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

315 reports to the FDA describe loose stool in dogs given Lufenuron + Milbemycin Oxime. That is 1.2% of all reports for this medicine, compared with 0.9% across reports for all dog medicines.

315Reports

23%Marked serious

28%Recovered

1.9%Died or euthanised

3 daysTypical onset

How soon it started

Same day

39 30%

1–2 days

26 20%

3–7 days

9 6.8%

1–4 weeks

38 29%

Over a month

20 15%

How the animals did

Recovered

86 27%

Recovered with lasting effects

2 0.6%

Still unwell when reported

41 13%

Died

6 1.9%

Not known

180 57%

Problems reported at the same time

Didn't stop worms

91 29%

Vomiting

84 27%

Didn't work as expected

84 27%

71 23%

63 20%

34 11%

12 3.8%

10 3.2%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause loose stool in dogs?: 315 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loose stool with similar medicines

Loose stool after Spinosad (Comfortis) 236 reports · 0.4% of its reports
Loose stool after Imidacloprid + Moxidectin (Advantage Multi) 161 reports · 1.2% of its reports
Loose stool after Nitenpyram (Capstar) 89 reports · 0.8% of its reports
Loose stool after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 116 reports · 1.2% of its reports
Loose stool after Fipronil + S-methoprene (Frontline Plus) 35 reports · 1.2% of its reports
Loose stool after Fipronil 21 reports · 1.5% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with loose stool