Didn't stop worms after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

4,911 reports to the FDA describe didn't stop worms in dogs given Lufenuron + Milbemycin Oxime. That is 19% of all reports for this medicine, compared with 8.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

4,911Reports

22%Marked serious

18%Recovered

0.8%Died or euthanised

21 daysTypical onset

How soon it started

Same day

29 2.7%

1–2 days

70 6.5%

3–7 days

135 12%

1–4 weeks

526 49%

Over a month

324 30%

How the animals did

Recovered

856 17%

Recovered with lasting effects

6 0.1%

Still unwell when reported

881 18%

Died

29 0.6%

Euthanised

9 0.2%

Not known

3,130 64%

Problems reported at the same time

Didn't work as expected

1,109 23%

558 11%

247 5.0%

117 2.4%

105 2.1%

91 1.9%

Drug dose administration interval too long

79 1.6%

Underdose

77 1.6%

Age of the animals

Under 1 year

522

1–3 years

1,674

4–7 years

1,316

8–11 years

922

12+ years

365

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause didn't stop worms in dogs?: 4,911 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 21 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't stop worms with similar medicines

Didn't stop worms after Spinosad (Comfortis) 60 reports · 0.1% of its reports
Didn't stop worms after Imidacloprid + Moxidectin (Advantage Multi) 821 reports · 6.3% of its reports
Didn't stop worms after Nitenpyram (Capstar) 28 reports · 0.3% of its reports
Didn't stop worms after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 2,556 reports · 26% of its reports
Didn't stop worms after Fipronil + S-methoprene (Frontline Plus) 57 reports · 1.9% of its reports
Didn't stop worms after Flumethrin + Imidacloprid (Seresto) 80 reports · 3.5% of its reports
Didn't stop worms after Fipronil 52 reports · 3.7% of its reports
Didn't stop worms after Imidacloprid + Permethrin + Pyriproxyfen 30 reports · 4.1% of its reports
Didn't stop worms after Imidacloprid + Permethrin 20 reports · 4.3% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with didn't stop worms