Didn't stop worms after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

2,556 reports to the FDA describe didn't stop worms in dogs given Lufenuron + Milbemycin Oxime + Praziquantel. That is 26% of all reports for this medicine, compared with 8.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

2,556Reports

47%Marked serious

14%Recovered

0.4%Died or euthanised

24 daysTypical onset

How soon it started

Same day

31 3.0%

1–2 days

59 5.7%

3–7 days

117 11%

1–4 weeks

466 45%

Over a month

367 35%

How the animals did

Recovered

360 14%

Recovered with lasting effects

5 0.2%

Still unwell when reported

1,076 42%

Died

6 0.2%

Euthanised

3 0.1%

Not known

1,106 43%

Problems reported at the same time

Didn't work as expected

300 12%

Diarrhea

157 6.1%

Vomiting

66 2.6%

Drug dose administration interval too long

35 1.4%

32 1.3%

30 1.2%

29 1.1%

28 1.1%

Age of the animals

Under 1 year

384

1–3 years

842

4–7 years

634

8–11 years

442

12+ years

166

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause didn't stop worms in dogs?: 2,556 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 24 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't stop worms with similar medicines

Didn't stop worms after Spinosad (Comfortis) 60 reports · 0.1% of its reports
Didn't stop worms after Lufenuron + Milbemycin Oxime (Sentinel) 4,911 reports · 19% of its reports
Didn't stop worms after Imidacloprid + Moxidectin (Advantage Multi) 821 reports · 6.3% of its reports
Didn't stop worms after Nitenpyram (Capstar) 28 reports · 0.3% of its reports
Didn't stop worms after Fipronil + S-methoprene (Frontline Plus) 57 reports · 1.9% of its reports
Didn't stop worms after Flumethrin + Imidacloprid (Seresto) 80 reports · 3.5% of its reports
Didn't stop worms after Fipronil 52 reports · 3.7% of its reports
Didn't stop worms after Imidacloprid + Permethrin + Pyriproxyfen 30 reports · 4.1% of its reports
Didn't stop worms after Imidacloprid + Permethrin 20 reports · 4.3% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with didn't stop worms