Drug dose administration interval too long after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

86 reports to the FDA describe drug dose administration interval too long in dogs given Lufenuron + Milbemycin Oxime + Praziquantel. That is 0.9% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

86Reports
28%Marked serious
3.5%Recovered
2.3%Died or euthanised
36 daysTypical onset
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How soon it started

Same day
1 5.6%
1–2 days
0 0.0%
3–7 days
0 0.0%
1–4 weeks
2 11%
Over a month
15 83%

How the animals did

Recovered
3 3.5%
Still unwell when reported
23 27%
Died
2 2.3%
Not known
58 67%

Problems reported at the same time

Age of the animals

Under 1 year
13
1–3 years
47
4–7 years
9
8–11 years
13
12+ years
3

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause drug dose administration interval too long in dogs?
86 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 36 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drug dose administration interval too long with similar medicines

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with drug dose administration interval too long