Didn't work as expected after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

The FDA has received 1,429 reports of didn't work as expected in dogs after Lufenuron + Milbemycin Oxime + Praziquantel. That is 14% of all reports for this medicine, compared with 13% across reports for all dog medicines.

1,429Reports

20%Marked serious

14%Recovered

0.8%Died or euthanised

19 daysTypical onset

How soon it started

Same day

21 2.7%

1–2 days

46 5.9%

3–7 days

100 13%

1–4 weeks

488 63%

Over a month

124 16%

How the animals did

Recovered

203 14%

Recovered with lasting effects

1 0.1%

Still unwell when reported

186 13%

Died

3 0.2%

Euthanised

8 0.6%

Not known

1,028 72%

Problems reported at the same time

Didn't stop worms

300 21%

Diarrhea

166 12%

Vomiting

64 4.5%

Didn't prevent heartworm

48 3.4%

Loss of appetite

45 3.1%

Loose stool

43 3.0%

Drug dose administration interval too long

37 2.6%

Lethargy

32 2.2%

Age of the animals

Under 1 year

232

1–3 years

480

4–7 years

401

8–11 years

229

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause didn't work as expected in dogs?: 1,429 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 19 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

Didn't work as expected after Spinosad (Comfortis) 1,731 reports · 3.0% of its reports
Didn't work as expected after Lufenuron + Milbemycin Oxime (Sentinel) 4,480 reports · 17% of its reports
Didn't work as expected after Imidacloprid + Moxidectin (Advantage Multi) 631 reports · 4.8% of its reports
Didn't work as expected after Nitenpyram (Capstar) 803 reports · 7.4% of its reports
Didn't work as expected after Fipronil + S-methoprene (Frontline Plus) 243 reports · 8.2% of its reports
Didn't work as expected after Flumethrin + Imidacloprid (Seresto) 209 reports · 9.2% of its reports
Didn't work as expected after Imidacloprid 105 reports · 5.5% of its reports
Didn't work as expected after Fipronil 152 reports · 11% of its reports
Didn't work as expected after Imidacloprid + Permethrin + Pyriproxyfen 30 reports · 4.1% of its reports
Didn't work as expected after Imidacloprid + Permethrin 70 reports · 15% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with didn't work as expected