Vomiting after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

1,925 reports to the FDA describe vomiting in dogs given Lufenuron + Milbemycin Oxime + Praziquantel. That is 19% of all reports for this medicine, compared with 28% across reports for all dog medicines.

1,925Reports

23%Marked serious

73%Recovered

1.3%Died or euthanised

Same dayTypical onset

How soon it started

Same day

955 68%

1–2 days

171 12%

3–7 days

48 3.4%

1–4 weeks

82 5.9%

Over a month

139 10.0%

How the animals did

Recovered

1,405 73%

Recovered with lasting effects

4 0.2%

Still unwell when reported

188 9.8%

Died

10 0.5%

Euthanised

15 0.8%

Not known

303 16%

Problems reported at the same time

309 16%

278 14%

230 12%

66 3.4%

Didn't work as expected

64 3.3%

Liver problems

54 2.8%

Tremors

51 2.6%

Behaviour change

39 2.0%

Age of the animals

Under 1 year

478

1–3 years

580

4–7 years

431

8–11 years

271

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause vomiting in dogs?: 1,925 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

Vomiting after Spinosad (Comfortis) 30,909 reports · 54% of its reports
Vomiting after Lufenuron + Milbemycin Oxime (Sentinel) 4,725 reports · 18% of its reports
Vomiting after Imidacloprid + Moxidectin (Advantage Multi) 1,904 reports · 15% of its reports
Vomiting after Nitenpyram (Capstar) 1,204 reports · 11% of its reports
Vomiting after Fipronil + S-methoprene (Frontline Plus) 627 reports · 21% of its reports
Vomiting after Flumethrin + Imidacloprid (Seresto) 295 reports · 13% of its reports
Vomiting after Imidacloprid 251 reports · 13% of its reports
Vomiting after Fipronil 417 reports · 30% of its reports
Vomiting after Lufenuron 325 reports · 32% of its reports
Vomiting after Imidacloprid + Permethrin + Pyriproxyfen 116 reports · 16% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with vomiting