Vomiting after Imidacloprid + Moxidectin (Advantage Multi) in dogs

The FDA has received 1,904 reports of vomiting in dogs after Imidacloprid + Moxidectin. That is 15% of all reports for this medicine, compared with 28% across reports for all dog medicines, so it is reported less often than average with this medicine.

1,904Reports

61%Marked serious

44%Recovered

4.3%Died or euthanised

1 daysTypical onset

How soon it started

Same day

570 44%

1–2 days

326 25%

3–7 days

102 7.9%

1–4 weeks

185 14%

Over a month

109 8.4%

How the animals did

Recovered

838 44%

Recovered with lasting effects

6 0.3%

Still unwell when reported

89 4.7%

Died

46 2.4%

Euthanised

36 1.9%

Not known

889 47%

Problems reported at the same time

605 32%

504 26%

422 22%

193 10%

150 7.9%

142 7.5%

135 7.1%

89 4.7%

Age of the animals

Under 1 year

453

1–3 years

575

4–7 years

432

8–11 years

255

12+ years

131

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause vomiting in dogs?: 1,904 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

Vomiting after Spinosad (Comfortis) 30,909 reports · 54% of its reports
Vomiting after Lufenuron + Milbemycin Oxime (Sentinel) 4,725 reports · 18% of its reports
Vomiting after Nitenpyram (Capstar) 1,204 reports · 11% of its reports
Vomiting after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 1,925 reports · 19% of its reports
Vomiting after Fipronil + S-methoprene (Frontline Plus) 627 reports · 21% of its reports
Vomiting after Flumethrin + Imidacloprid (Seresto) 295 reports · 13% of its reports
Vomiting after Imidacloprid 251 reports · 13% of its reports
Vomiting after Fipronil 417 reports · 30% of its reports
Vomiting after Lufenuron 325 reports · 32% of its reports
Vomiting after Imidacloprid + Permethrin + Pyriproxyfen 116 reports · 16% of its reports

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with vomiting