Vomiting after Imidacloprid + Permethrin + Pyriproxyfen in dogs

The FDA has received 116 reports of vomiting in dogs after Imidacloprid + Permethrin + Pyriproxyfen. That is 16% of all reports for this medicine, compared with 28% across reports for all dog medicines, so it is reported less often than average with this medicine.

116Reports

43%Marked serious

45%Recovered

4.3%Died or euthanised

14 daysTypical onset

How soon it started

Same day

25 28%

1–2 days

9 10%

3–7 days

7 7.8%

1–4 weeks

20 22%

Over a month

29 32%

How the animals did

Recovered

52 45%

Still unwell when reported

19 16%

Died

2 1.7%

Euthanised

3 2.6%

Not known

40 34%

Problems reported at the same time

43 37%

35 30%

24 21%

18 16%

15 13%

Restlessness or agitation

13 11%

Seizures

10 8.6%

Skin redness

9 7.8%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar).

Questions owners ask

Can Imidacloprid + Permethrin + Pyriproxyfen cause vomiting in dogs?: 116 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 14 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

Vomiting after Spinosad (Comfortis) 30,909 reports · 54% of its reports
Vomiting after Lufenuron + Milbemycin Oxime (Sentinel) 4,725 reports · 18% of its reports
Vomiting after Imidacloprid + Moxidectin (Advantage Multi) 1,904 reports · 15% of its reports
Vomiting after Nitenpyram (Capstar) 1,204 reports · 11% of its reports
Vomiting after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 1,925 reports · 19% of its reports
Vomiting after Fipronil + S-methoprene (Frontline Plus) 627 reports · 21% of its reports
Vomiting after Flumethrin + Imidacloprid (Seresto) 295 reports · 13% of its reports
Vomiting after Imidacloprid 251 reports · 13% of its reports
Vomiting after Fipronil 417 reports · 30% of its reports
Vomiting after Lufenuron 325 reports · 32% of its reports

All reported side effects of Imidacloprid + Permethrin + Pyriproxyfen in dogs · Medicines most reported with vomiting