Seizures after Imidacloprid + Permethrin + Pyriproxyfen in dogs

34 reports to the FDA describe seizures in dogs given Imidacloprid + Permethrin + Pyriproxyfen. That is 4.6% of all reports for this medicine, compared with 4.4% across reports for all dog medicines.

34Reports

97%Marked serious

44%Recovered

12%Died or euthanised

61 daysTypical onset

How soon it started

Same day

2 9.1%

1–2 days

4 18%

3–7 days

2 9.1%

1–4 weeks

3 14%

Over a month

11 50%

How the animals did

Recovered

15 44%

Still unwell when reported

7 21%

Died

2 5.9%

Euthanised

2 5.9%

Not known

8 24%

Problems reported at the same time

11 32%

10 29%

6 18%

5 15%

5 15%

4 12%

4 12%

4 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar).

Questions owners ask

Can Imidacloprid + Permethrin + Pyriproxyfen cause seizures in dogs?: 34 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 61 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Seizures with similar medicines

Seizures after Spinosad (Comfortis) 2,116 reports · 3.7% of its reports
Seizures after Lufenuron + Milbemycin Oxime (Sentinel) 937 reports · 3.6% of its reports
Seizures after Imidacloprid + Moxidectin (Advantage Multi) 520 reports · 4.0% of its reports
Seizures after Nitenpyram (Capstar) 331 reports · 3.1% of its reports
Seizures after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 279 reports · 2.8% of its reports
Seizures after Fipronil + S-methoprene (Frontline Plus) 214 reports · 7.2% of its reports
Seizures after Flumethrin + Imidacloprid (Seresto) 123 reports · 5.4% of its reports
Seizures after Imidacloprid 43 reports · 2.3% of its reports
Seizures after Fipronil 72 reports · 5.1% of its reports
Seizures after Lufenuron 65 reports · 6.4% of its reports

All reported side effects of Imidacloprid + Permethrin + Pyriproxyfen in dogs · Medicines most reported with seizures