Imidacloprid + Permethrin + Pyriproxyfen side effects in dogs
740 reports sent to the FDA between 2011 and 2026 involve Imidacloprid + Permethrin + Pyriproxyfen in dogs. The most reported problems were itching, vomiting, lethargy. 31% were marked serious, and where it was recorded, signs eased after stopping the medicine in 100% of cases.
740Reports
31%Marked serious
0.0%Only medicine involved
24%Recovered
3.9%Died or euthanised
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About this medicine
Imidacloprid kills fleas (spot-on or collar).
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (507 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Labrador Retriever 35 reports
- Shih Tzu 26 reports
- German Pomeranian Spitz 22 reports
- Chihuahua 22 reports
- German Shepherd Dog 19 reports
- Australian Shepherd Dog 15 reports
- Golden Retriever 14 reports
- Shetland Sheepdog 14 reports
- Maltese 12 reports
- Yorkshire Terrier 12 reports
Other flea and tick treatments for dogs
Spinosad (Comfortis)57,095 reports · 7.7% seriousLufenuron + Milbemycin Oxime (Sentinel)26,051 reports · 24% seriousImidacloprid + Moxidectin (Advantage Multi)13,117 reports · 57% seriousNitenpyram (Capstar)10,782 reports · 10.0% seriousLufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum)9,966 reports · 40% seriousFipronil + S-methoprene (Frontline Plus)2,954 reports · 49% seriousFlumethrin + Imidacloprid (Seresto)2,273 reports · 25% seriousImidacloprid1,908 reports · 11% serious