Wobbliness (ataxia) after Imidacloprid + Permethrin + Pyriproxyfen in dogs

29 reports to the FDA describe wobbliness (ataxia) in dogs given Imidacloprid + Permethrin + Pyriproxyfen. That is 3.9% of all reports for this medicine, compared with 2.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

29Reports

66%Marked serious

41%Recovered

3.4%Died or euthanised

12 daysTypical onset

How soon it started

Same day

5 23%

1–2 days

1 4.5%

3–7 days

5 23%

1–4 weeks

6 27%

Over a month

5 23%

How the animals did

Recovered

11 38%

Recovered with lasting effects

1 3.4%

Still unwell when reported

5 17%

Died

1 3.4%

Not known

11 38%

Problems reported at the same time

Lethargy

12 41%

Loss of appetite

10 34%

Weakness

6 21%

6 21%

5 17%

5 17%

4 14%

4 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar).

Questions owners ask

Can Imidacloprid + Permethrin + Pyriproxyfen cause wobbliness (ataxia) in dogs?: 29 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 12 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Wobbliness (ataxia) with similar medicines

Wobbliness (ataxia) after Spinosad (Comfortis) 1,456 reports · 2.6% of its reports
Wobbliness (ataxia) after Lufenuron + Milbemycin Oxime (Sentinel) 504 reports · 1.9% of its reports
Wobbliness (ataxia) after Imidacloprid + Moxidectin (Advantage Multi) 658 reports · 5.0% of its reports
Wobbliness (ataxia) after Nitenpyram (Capstar) 219 reports · 2.0% of its reports
Wobbliness (ataxia) after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 167 reports · 1.7% of its reports
Wobbliness (ataxia) after Fipronil + S-methoprene (Frontline Plus) 79 reports · 2.7% of its reports
Wobbliness (ataxia) after Flumethrin + Imidacloprid (Seresto) 45 reports · 2.0% of its reports
Wobbliness (ataxia) after Imidacloprid 61 reports · 3.2% of its reports
Wobbliness (ataxia) after Fipronil 32 reports · 2.3% of its reports
Wobbliness (ataxia) after Lufenuron 27 reports · 2.7% of its reports

All reported side effects of Imidacloprid + Permethrin + Pyriproxyfen in dogs · Medicines most reported with wobbliness (ataxia)