Wobbliness (ataxia) after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

The FDA has received 504 reports of wobbliness (ataxia) in dogs after Lufenuron + Milbemycin Oxime. That is 1.9% of all reports for this medicine, compared with 2.6% across reports for all dog medicines.

504Reports

36%Marked serious

32%Recovered

6.2%Died or euthanised

1 daysTypical onset

How soon it started

Same day

93 44%

1–2 days

50 24%

3–7 days

18 8.5%

1–4 weeks

17 8.0%

Over a month

34 16%

How the animals did

Recovered

157 31%

Recovered with lasting effects

4 0.8%

Still unwell when reported

62 12%

Died

17 3.4%

Euthanised

14 2.8%

Not known

250 50%

Problems reported at the same time

191 38%

120 24%

119 24%

84 17%

61 12%

60 12%

54 11%

44 8.7%

Age of the animals

Under 1 year

147

1–3 years

4–7 years

8–11 years

102

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause wobbliness (ataxia) in dogs?: 504 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Wobbliness (ataxia) with similar medicines

Wobbliness (ataxia) after Spinosad (Comfortis) 1,456 reports · 2.6% of its reports
Wobbliness (ataxia) after Imidacloprid + Moxidectin (Advantage Multi) 658 reports · 5.0% of its reports
Wobbliness (ataxia) after Nitenpyram (Capstar) 219 reports · 2.0% of its reports
Wobbliness (ataxia) after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 167 reports · 1.7% of its reports
Wobbliness (ataxia) after Fipronil + S-methoprene (Frontline Plus) 79 reports · 2.7% of its reports
Wobbliness (ataxia) after Flumethrin + Imidacloprid (Seresto) 45 reports · 2.0% of its reports
Wobbliness (ataxia) after Imidacloprid 61 reports · 3.2% of its reports
Wobbliness (ataxia) after Fipronil 32 reports · 2.3% of its reports
Wobbliness (ataxia) after Lufenuron 27 reports · 2.7% of its reports
Wobbliness (ataxia) after Imidacloprid + Permethrin + Pyriproxyfen 29 reports · 3.9% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with wobbliness (ataxia)