Accidental exposure after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

234 reports to the FDA describe accidental exposure in dogs given Lufenuron + Milbemycin Oxime. That is 0.9% of all reports for this medicine, compared with 1.5% across reports for all dog medicines, so it is reported less often than average with this medicine.

234Reports

14%Marked serious

26%Recovered

1.3%Died or euthanised

Same dayTypical onset

How soon it started

Same day

28 61%

1–2 days

5 11%

3–7 days

2 4.3%

1–4 weeks

2 4.3%

Over a month

9 20%

How the animals did

Recovered

58 25%

Recovered with lasting effects

2 0.9%

Still unwell when reported

13 5.6%

Died

2 0.9%

Euthanised

1 0.4%

Not known

158 68%

Problems reported at the same time

95 41%

86 37%

63 27%

54 23%

47 20%

29 12%

16 6.8%

Restlessness or agitation

9 3.8%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause accidental exposure in dogs?: 234 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Accidental exposure with similar medicines

Accidental exposure after Spinosad (Comfortis) 1,195 reports · 2.1% of its reports
Accidental exposure after Imidacloprid + Moxidectin (Advantage Multi) 223 reports · 1.7% of its reports
Accidental exposure after Nitenpyram (Capstar) 76 reports · 0.7% of its reports
Accidental exposure after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 53 reports · 0.5% of its reports
Accidental exposure after Imidacloprid 31 reports · 1.6% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with accidental exposure