Restlessness or agitation after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

255 reports to the FDA describe restlessness or agitation in dogs given Lufenuron + Milbemycin Oxime. That is 1.0% of all reports for this medicine, compared with 1.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

255Reports

40%Marked serious

34%Recovered

4.7%Died or euthanised

1 daysTypical onset

How soon it started

Same day

57 48%

1–2 days

18 15%

3–7 days

5 4.2%

1–4 weeks

12 10%

Over a month

27 23%

How the animals did

Recovered

85 33%

Recovered with lasting effects

1 0.4%

Still unwell when reported

33 13%

Died

6 2.4%

Euthanised

6 2.4%

Not known

124 49%

Problems reported at the same time

73 29%

60 24%

55 22%

47 18%

41 16%

35 14%

35 14%

34 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause restlessness or agitation in dogs?: 255 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

Restlessness or agitation after Spinosad (Comfortis) 658 reports · 1.2% of its reports
Restlessness or agitation after Imidacloprid + Moxidectin (Advantage Multi) 835 reports · 6.4% of its reports
Restlessness or agitation after Nitenpyram (Capstar) 596 reports · 5.5% of its reports
Restlessness or agitation after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 73 reports · 0.7% of its reports
Restlessness or agitation after Fipronil + S-methoprene (Frontline Plus) 119 reports · 4.0% of its reports
Restlessness or agitation after Flumethrin + Imidacloprid (Seresto) 68 reports · 3.0% of its reports
Restlessness or agitation after Imidacloprid 44 reports · 2.3% of its reports
Restlessness or agitation after Fipronil 40 reports · 2.8% of its reports
Restlessness or agitation after Imidacloprid + Permethrin + Pyriproxyfen 56 reports · 7.6% of its reports
Restlessness or agitation after Cyphenothrin + Fipronil + S-methoprene 222 reports · 34% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with restlessness or agitation