Behaviour change after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

358 reports to the FDA describe behaviour change in dogs given Lufenuron + Milbemycin Oxime. That is 1.4% of all reports for this medicine, compared with 2.5% across reports for all dog medicines, so it is reported less often than average with this medicine.

358Reports

46%Marked serious

41%Recovered

5.9%Died or euthanised

1 daysTypical onset

How soon it started

Same day

75 42%

1–2 days

30 17%

3–7 days

14 7.9%

1–4 weeks

17 9.6%

Over a month

41 23%

How the animals did

Recovered

139 39%

Recovered with lasting effects

7 2.0%

Still unwell when reported

54 15%

Died

16 4.5%

Euthanised

5 1.4%

Not known

137 38%

Problems reported at the same time

140 39%

89 25%

86 24%

59 16%

43 12%

42 12%

Restlessness or agitation

41 11%

Itching

39 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

108

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause behaviour change in dogs?: 358 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

Behaviour change after Spinosad (Comfortis) 1,176 reports · 2.1% of its reports
Behaviour change after Imidacloprid + Moxidectin (Advantage Multi) 1,205 reports · 9.2% of its reports
Behaviour change after Nitenpyram (Capstar) 323 reports · 3.0% of its reports
Behaviour change after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 128 reports · 1.3% of its reports
Behaviour change after Fipronil + S-methoprene (Frontline Plus) 181 reports · 6.1% of its reports
Behaviour change after Flumethrin + Imidacloprid (Seresto) 167 reports · 7.3% of its reports
Behaviour change after Imidacloprid 94 reports · 4.9% of its reports
Behaviour change after Fipronil 66 reports · 4.7% of its reports
Behaviour change after Lufenuron 20 reports · 2.0% of its reports
Behaviour change after Imidacloprid + Permethrin + Pyriproxyfen 70 reports · 9.5% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with behaviour change