Breathing problems after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

393 reports to the FDA describe breathing problems in dogs given Lufenuron + Milbemycin Oxime. That is 1.5% of all reports for this medicine, compared with 2.7% across reports for all dog medicines, so it is reported less often than average with this medicine.

393Reports
53%Marked serious
36%Recovered
16%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
99 47%
1–2 days
27 13%
3–7 days
15 7.1%
1–4 weeks
23 11%
Over a month
47 22%

How the animals did

Recovered
132 34%
Recovered with lasting effects
8 2.0%
Still unwell when reported
53 13%
Died
42 11%
Euthanised
21 5.3%
Not known
137 35%

Problems reported at the same time

Age of the animals

Under 1 year
40
1–3 years
96
4–7 years
99
8–11 years
96
12+ years
54

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause breathing problems in dogs?
393 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Breathing problems with similar medicines

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with breathing problems