Breathing problems after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

137 reports to the FDA describe breathing problems in dogs given Lufenuron + Milbemycin Oxime + Praziquantel. That is 1.4% of all reports for this medicine, compared with 2.7% across reports for all dog medicines, so it is reported less often than average with this medicine.

137Reports
79%Marked serious
47%Recovered
15%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
62 58%
1–2 days
16 15%
3–7 days
9 8.5%
1–4 weeks
5 4.7%
Over a month
14 13%

How the animals did

Recovered
64 47%
Recovered with lasting effects
1 0.7%
Still unwell when reported
23 17%
Died
12 8.8%
Euthanised
9 6.6%
Not known
28 20%

Problems reported at the same time

Age of the animals

Under 1 year
18
1–3 years
38
4–7 years
40
8–11 years
26
12+ years
12

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause breathing problems in dogs?
137 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Breathing problems with similar medicines

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with breathing problems