Death after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs
The FDA has received 139 reports of death in dogs after Lufenuron + Milbemycin Oxime + Praziquantel. That is 1.4% of all reports for this medicine, compared with 5.2% across reports for all dog medicines, so it is reported less often than average with this medicine.
139Reports
98%Marked serious
0.0%Recovered
99%Died or euthanised
2 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.
Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Lufenuron + Milbemycin Oxime + Praziquantel cause death in dogs?
- 139 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 2 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Death with similar medicines
- Death after Spinosad (Comfortis) 1,441 reports · 2.5% of its reports
- Death after Lufenuron + Milbemycin Oxime (Sentinel) 545 reports · 2.1% of its reports
- Death after Imidacloprid + Moxidectin (Advantage Multi) 511 reports · 3.9% of its reports
- Death after Nitenpyram (Capstar) 349 reports · 3.2% of its reports
- Death after Fipronil + S-methoprene (Frontline Plus) 98 reports · 3.3% of its reports
- Death after Flumethrin + Imidacloprid (Seresto) 69 reports · 3.0% of its reports
- Death after Imidacloprid 48 reports · 2.5% of its reports
- Death after Fipronil 52 reports · 3.7% of its reports
- Death after Lufenuron 74 reports · 7.3% of its reports
- Death after Imidacloprid + Permethrin + Pyriproxyfen 29 reports · 3.9% of its reports
All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with death