Seizures after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs
The FDA has received 279 reports of seizures in dogs after Lufenuron + Milbemycin Oxime + Praziquantel. That is 2.8% of all reports for this medicine, compared with 4.4% across reports for all dog medicines, so it is reported less often than average with this medicine.
279Reports
67%Marked serious
57%Recovered
6.5%Died or euthanised
2 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.
Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Lufenuron + Milbemycin Oxime + Praziquantel cause seizures in dogs?
- 279 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 2 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Seizures with similar medicines
- Seizures after Spinosad (Comfortis) 2,116 reports · 3.7% of its reports
- Seizures after Lufenuron + Milbemycin Oxime (Sentinel) 937 reports · 3.6% of its reports
- Seizures after Imidacloprid + Moxidectin (Advantage Multi) 520 reports · 4.0% of its reports
- Seizures after Nitenpyram (Capstar) 331 reports · 3.1% of its reports
- Seizures after Fipronil + S-methoprene (Frontline Plus) 214 reports · 7.2% of its reports
- Seizures after Flumethrin + Imidacloprid (Seresto) 123 reports · 5.4% of its reports
- Seizures after Imidacloprid 43 reports · 2.3% of its reports
- Seizures after Fipronil 72 reports · 5.1% of its reports
- Seizures after Lufenuron 65 reports · 6.4% of its reports
- Seizures after Imidacloprid + Permethrin + Pyriproxyfen 34 reports · 4.6% of its reports
All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with seizures