Disorientation after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

The FDA has received 67 reports of disorientation in dogs after Lufenuron + Milbemycin Oxime + Praziquantel. That is 0.7% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.

67Reports

72%Marked serious

48%Recovered

7.5%Died or euthanised

1 daysTypical onset

How soon it started

Same day

20 50%

1–2 days

9 23%

3–7 days

2 5.0%

1–4 weeks

3 7.5%

Over a month

6 15%

How the animals did

Recovered

31 46%

Recovered with lasting effects

1 1.5%

Still unwell when reported

21 31%

Died

3 4.5%

Euthanised

2 3.0%

Not known

9 13%

Problems reported at the same time

22 33%

18 27%

15 22%

14 21%

14 21%

14 21%

12 18%

10 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause disorientation in dogs?: 67 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Disorientation with similar medicines

Disorientation after Spinosad (Comfortis) 497 reports · 0.9% of its reports
Disorientation after Lufenuron + Milbemycin Oxime (Sentinel) 154 reports · 0.6% of its reports
Disorientation after Imidacloprid + Moxidectin (Advantage Multi) 182 reports · 1.4% of its reports
Disorientation after Nitenpyram (Capstar) 183 reports · 1.7% of its reports
Disorientation after Fipronil + S-methoprene (Frontline Plus) 34 reports · 1.2% of its reports
Disorientation after Imidacloprid 23 reports · 1.2% of its reports
Disorientation after Fipronil 24 reports · 1.7% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with disorientation