Tremors after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

The FDA has received 213 reports of tremors in dogs after Lufenuron + Milbemycin Oxime + Praziquantel. That is 2.1% of all reports for this medicine, compared with 3.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

213Reports

62%Marked serious

49%Recovered

1.9%Died or euthanised

Same dayTypical onset

How soon it started

Same day

87 53%

1–2 days

28 17%

3–7 days

16 9.8%

1–4 weeks

18 11%

Over a month

15 9.1%

How the animals did

Recovered

101 47%

Recovered with lasting effects

3 1.4%

Still unwell when reported

51 24%

Died

1 0.5%

Euthanised

3 1.4%

Not known

54 25%

Problems reported at the same time

70 33%

51 24%

43 20%

40 19%

39 18%

27 13%

22 10%

20 9.4%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause tremors in dogs?: 213 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Tremors with similar medicines

Tremors after Spinosad (Comfortis) 2,268 reports · 4.0% of its reports
Tremors after Lufenuron + Milbemycin Oxime (Sentinel) 590 reports · 2.3% of its reports
Tremors after Imidacloprid + Moxidectin (Advantage Multi) 837 reports · 6.4% of its reports
Tremors after Nitenpyram (Capstar) 402 reports · 3.7% of its reports
Tremors after Fipronil + S-methoprene (Frontline Plus) 141 reports · 4.8% of its reports
Tremors after Flumethrin + Imidacloprid (Seresto) 66 reports · 2.9% of its reports
Tremors after Imidacloprid 58 reports · 3.0% of its reports
Tremors after Fipronil 65 reports · 4.6% of its reports
Tremors after Lufenuron 33 reports · 3.2% of its reports
Tremors after Imidacloprid + Permethrin + Pyriproxyfen 35 reports · 4.7% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with tremors