Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) side effects in dogs
9,966 reports sent to the FDA between 2011 and 2026 involve Lufenuron + Milbemycin Oxime + Praziquantel in dogs. The most reported problems were vomiting, diarrhea, lethargy. 40% were marked serious, and where it was recorded, signs eased after stopping the medicine in 11% of cases.
About this medicine
Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.
Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (4,951 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Labrador Retriever 1,081 reports
- German Shepherd Dog 391 reports
- Golden Retriever 352 reports
- Beagle 231 reports
- Chihuahua 218 reports
- Pit Bull 204 reports
- Yorkshire Terrier 181 reports
- Boxer (german Boxer) 168 reports
- Shih Tzu 164 reports
- Australian Shepherd Dog 161 reports