Didn't stop fleas after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

498 reports to the FDA describe didn't stop fleas in dogs given Lufenuron + Milbemycin Oxime + Praziquantel. That is 5.0% of all reports for this medicine, compared with 6.2% across reports for all dog medicines.

498Reports

12%Marked serious

4.2%Recovered

0.0%Died or euthanised

7 daysTypical onset

How soon it started

Same day

75 32%

1–2 days

11 4.7%

3–7 days

37 16%

1–4 weeks

62 27%

Over a month

48 21%

How the animals did

Recovered

21 4.2%

Still unwell when reported

231 46%

Not known

246 49%

Problems reported at the same time

Itching

18 3.6%

Drug dose administration interval too short

10 2.0%

Didn't stop worms

8 1.6%

Skin rash or irritation

7 1.4%

Overdose

7 1.4%

Underdose

5 1.0%

Skin sore

5 1.0%

Didn't work as expected

4 0.8%

Age of the animals

Under 1 year

1–3 years

106

4–7 years

115

8–11 years

100

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause didn't stop fleas in dogs?: 498 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 7 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't stop fleas with similar medicines

Didn't stop fleas after Spinosad (Comfortis) 13,280 reports · 23% of its reports
Didn't stop fleas after Lufenuron + Milbemycin Oxime (Sentinel) 977 reports · 3.8% of its reports
Didn't stop fleas after Imidacloprid + Moxidectin (Advantage Multi) 1,444 reports · 11% of its reports
Didn't stop fleas after Nitenpyram (Capstar) 6,142 reports · 57% of its reports
Didn't stop fleas after Fipronil + S-methoprene (Frontline Plus) 576 reports · 19% of its reports
Didn't stop fleas after Flumethrin + Imidacloprid (Seresto) 882 reports · 39% of its reports
Didn't stop fleas after Imidacloprid 1,054 reports · 55% of its reports
Didn't stop fleas after Fipronil 394 reports · 28% of its reports
Didn't stop fleas after Lufenuron 44 reports · 4.3% of its reports
Didn't stop fleas after Imidacloprid + Permethrin + Pyriproxyfen 219 reports · 30% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with didn't stop fleas